Contract Associate Scientist, Process Development
* 200 Cambridgepark Dr, Cambridge, MA 02140, USA
Recent advances in T-cell engineering and antibody therapeutics have led to phenomenal results in treating cancer patients, opening the possibility for combining these powerful therapeutic modalities. Unum Therapeutics aims to transform cancer treatment through the discovery, development, and commercialization of novel cellular immunotherapies. We're moving forward fast, are you? Visit [Click here to apply]
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What will you be doing in this 12 month contract position?
Working within the process development group, you will assist in the development and optimization of closed system clinical scale manufacturing processes to support ongoing Phase I/II cancer immunotherapy trials.
We are seeking a 12-month contractor interested in cell and gene therapy to be a key contributor to a new set of projects within our process development efforts at Unum. Activities include but are not limited to the following:
* Evaluate next generation technologies and equipment for closed system clinical scale manufacturing of autologous cellular therapy products
* Work collaboratively and cross functionally with the vector process development and analytics group to develop alternative methods for transduction of autologous T cells with retroviral vectors
* Design, generate, analyze, and interpret experimental data from in vitro, primary human cell based assays (flow cytometry, cell counting, RT-PCR and ELISA) to inform process development in the optimization of manufacturing our autologous cell based immunotherapy.
* Troubleshoot, solve difficult problems, develop assay improvements and maintain careful record-keeping.
* Communicate and present scientific findings at group and company meetings.
* Maintain detailed experimental records and laboratory notebook.
* Contribute to other initiatives as they arise in our fun, fast paced startup environment.
Who are we seeking?
* An independent, flexible, high energy candidate with a BS w/ 3-5+ yrs. or MS w/ 1-3 yrs. of relevant experience in an industry (preferred) or academic setting.
* Demonstrated competence in mammalian cell/tissue culture techniques and flow cytometry.
* Demonstrated competence in execution of primary T-cell based assays such as activation, proliferation, cytotoxicity and cytokine release preferred.
* Experience performing cell-based assays across multiple assay platforms (e.g. flow cytometry, ELISA, RT-PCR, luminescence).
* Experience making and using retroviral vectors.
* Experience with cell therapy processing equipment such as Elutra, Cell Saver Elite, Sepax, Prodigy, CliniMACS, Wave Bioreactors, and LOVO are a plus.
* Experience immunology, oncology and/or immuno-oncology is a plus.
* Outstanding written and oral communication skills and ability to work collaboratively.
All your information will be kept confidential according to EEO guidelines.