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Scientist / Senior Scientist - T Cell Therapy job in Littlemore at Northreach

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Scientist / Senior Scientist - T Cell Therapy at Northreach

Scientist / Senior Scientist - T Cell Therapy

Northreach Littlemore, Oxfordshire Full Time
£35,000 - £50,000/Year
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My client is a fast growing and well backed T Cell therapy business in Oxford and are currently recruiting for both a Scientist and a Senior Scientist to join their already well established team

You will support the efforts in the Cellular Immunology group to identify the most immunogenic antigens to identify optimal antigens for targeting with T cell receptors, vaccines, or other modalities, and selection and characterisation of the most effective T cell receptors for further development. This data will drive the development of biologics and cell therapies to make a meaningful difference for patients suffering from cancer.

You will be responsible for:

* Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams

* Providing scientific leadership, supervision, coaching and mentorship for less experienced scientists in your team, as well as other scientists in our matrixed environment

* Provide functional leadership for company projects from early discovery through to candidate selection including regular updates to the company’s senior leadership team

* Providing expert technical direction, challenge and problem solving in projects

* Working closely with other research functional teams (e.g. Bioinformatics and Immunopeptidomics) to validate the role of novel T cell antigens and cognate T cell receptors in cancer. This work will form the basis of T cell therapies for cancer

* Designing, conducting and evaluating experiments to establish the efficacy of T cell receptors against novel cancer antigens

* T cell profiling for very low frequency cells (use of Elispot, multimers), FACS sorting/analysis, CTL cloning and recombinant T cell receptor expression/characterization. Killing assays using flow and electrical impedence-based methodology.

* Establishment of robust T cell expansion protocols for clinical application

Minimum Qualifications and Experience required

* Proven experience of working with CAR-T/TCR-T methodologies ideally in a biotech setting or alternatively in an academic setting (minimum of 3-5 years)

* Proven experience of working on cell-based therapies

* A PhD in a relevant scientific discipline, strong expertise in immunology preferred.

* Proven experience of relevant Immunological laboratory techniques.

* Previous proven experience of managing and mentoring other scientists

For more information on this amazing and growing Biotech please get in touch ASAP

 

Recommended Skills

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Job ID: 215277042

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